Protein science, assay rescue, and discovery strategy for hard biology programs. The right answers, fast.
37C provides artful solutions to scientific challenges
Focused support for research bottlenecks
We work on technically difficult problems where standard CRO workflows are too rigid, internal teams are overloaded, or the next experiment is unclear. We offer expert scientific judgment coupled with the lab capability to put ideas to the test - quickly and effectively.
Difficult proteins and custom reagents
High-quality reagents: expression, purification, construct design, and QC for proteins used in crystallography, cryo-EM, biophysics, DEL/HTS, and functional assays. We also generate custom enzymes, protein conjugates, cell lines, bacterial strains, and other hard-to-source reagents.
Membrane protein expertise: we produce native-like, active membrane proteins in traditional detergent micelles, protein nanodiscs, or using the cutting-edge detergent-free copolymer embedding.
Target strategy and program advisory
Target evaluation & discovery strategy: literature and patent landscape analysis, competitive assessment, target validation strategy, and program design. We help teams decide what to work on and how to de-risk it.
IP and scientific writing: patent/domain/prior art analysis, expert craftsmanship for white papers, investor materials, grants, etc.
Program advisory and management: senior scientific input for discovery teams that need experienced judgment and project management/leadership without full-time hire - assay strategy, data interpretation, support for key go/no-go decisions.
Target Exploration and Assay Development
Target assessment, design, evaluation, and optimization for DEL, HTS, or Biophysics. Site specific biotinylation, alternative immobilization and tagging techniques, thorough QC that distinguishes a usable screen from a failed one.
Assay development, enzymology, de novo assay design and HT-format adaptation. Biochemical assays with difficult or unusual substrates, biophysical assays adapted to HT format, cell-based assays and more.
Targets we work on
Enzymes: kinases, phosphatases, proteases, deubiquitinases (DUBs), E3 ligases, methyltransferases, demethylases, acetyltransferases, deacetylases, GTPases, ATPases, polymerases, helicases
Protein-protein interaction targets: cytokines and cytokine receptors, scaffold and adapter proteins, transcription factors, molecular glue and PROTAC ternary complexes, checkpoint regulators.
Known challenges: membrane proteins, nucleic acid binders, intrinsically disordered proteins, large complexes - we create bespoke solutions to difficult problems.
Structure-guided, experimentally grounded
Structural and mechanistic reasoning is our foundation.
We use modeling, AI-assisted tools, computational chemistry, and molecular design where useful — but always tied to experiments that can test the idea.